Anafranil 25mg Tablet 10pcs

Uses of Anafranil 25mg Tablet

• Obsessive-Compulsive Disorder (OCD)
• Depression
• Panic disorder
• Cataplexy
• Narcolepsy
• Phobias
• Premature ejaculation
• Enuresis
• Trichotillomania

How does Anafranil 25mg Tablet work?

Clomipramine is a potent inhibitor of serotonin re-uptake in the brain. It has significant antagonism at cholinergic and α1-receptors and weak antagonism at dopamine receptors, providing antidepressant, sedative, and anticholinergic effects.

Side Effects of Anafranil 25mg Tablet

Common side effects include gastrointestinal disturbances, headache, dizziness, nausea, constipation, dry mouth, increased sweating, tremor, difficulty urinating, eye problems, tiredness, sleepiness, sexual disturbances, and restlessness.

Quick Suggestions:

• It may take 4 to 6 weeks for Anafranil 25 to start working. Continue taking it as prescribed.
• Take it at bedtime to avoid sleepiness during the day.
• Avoid alcohol consumption as it may cause excessive sleepiness.
• Monitor your weight during the treatment as this medicine can increase appetite and cause weight gain.
• Report any sudden mood changes or suicidal thoughts to your doctor.

Dosage of Anafranil 25mg Tablet

Adult Dose

• Cataplexy with Narcolepsy: Start with 10 mg daily, gradually increasing to 10-75 mg daily. Elderly patients may need dose adjustments.
• OCD, Panic Disorder, Phobias: Start with 25 mg daily, increasing to 100-150 mg daily over two weeks. Maximum 250 mg daily.
• Depression: Start with 10 mg daily; increase gradually to 30-150 mg daily if needed. Severe cases may require up to 250 mg or more. Elderly: Start with 10 mg daily, increasing to 30-75 mg over 10 days. Maximum 100-150 mg daily.

Child Dose

• OCD: For children over 10 years, start with 25 mg daily, gradually increasing to a maximum of 3 mg/kg/day or 100 mg/day, whichever is less. Further, increase up to 3 mg/kg/day or 200 mg/day if tolerated. Safety and efficacy are not established for children under 10 years.

Pharmacology

Clomipramine Hydrochloride, a tricyclic antidepressant in the dibenzazepine class, is believed to affect obsessive and compulsive behaviors by impacting serotonergic neuronal transmission. While the precise neurochemical mechanism is not fully understood, it is known to inhibit serotonin (5-HT) reuptake, which is considered significant in managing symptoms like obsessions and compulsions, thereby improving social interactions.

Administration of Anafranil 25mg Tablet

• Take medication as prescribed by your doctor.
• Swallow the capsules whole with water.
• Continue taking the medication until your doctor advises you to stop.
• Do not discontinue use because you do not feel immediate improvement; it may take up to 4 weeks to see the effects.
• The medication can be taken as a single dose at night or in smaller doses throughout the day.

Anafranil may interact with:

• Depression medications, particularly:
  • MAOIs (e.g., tranylcypromine, phenelzine, moclobemide)
  • SSRIs (e.g., fluoxetine, fluvoxamine, paroxetine, sertraline)
  • SNaRIs (e.g., venlafaxine)
  • Tricyclic and tetracyclic antidepressants (e.g., amitriptyline, dothiepin, maprotiline)
• Diuretics (e.g., bendroflumethiazide, furosemide)
• Anesthetics
• Blood pressure medications (Beta-blockers)
• Anticoagulants

Anafranil should not be used in patients who:

• Have shown hypersensitivity to Clomipramine Hydrochloride or other tricyclic antidepressants in the dibenzazepine group
• Are in the acute recovery phase following a myocardial infarction
• Are currently using or have used MAO inhibitors within the last 14 days

Pregnancy & Lactation

There are no adequate, well-controlled studies on the safety of Clomipramine during pregnancy. Limited data suggest it may be excreted in human breast milk, posing a known risk to the fetus.

Consult your doctor or pharmacist before taking Anafranil if you:

• Have had suicidal thoughts
• Suffer from epilepsy (seizures)
• Have had a head injury or brain damage
• Are scheduled for electric shock therapy (ECT)
• Have heart problems
• Have low potassium levels (hypokalaemia)
• Have kidney disease
• Have schizophrenia or other mental health conditions
• Have a blood disorder
• Have an overactive thyroid gland
• Have chronic severe constipation
• Have a tumor of the adrenal gland (e.g., phaeochromocytoma or neuroblastoma)
• Have liver disease
• Have low blood pressure
• Wear contact lenses

Storage Conditions:

Store below 30°C, away from light and out of the reach of children.